Patch clamp induced Ca2+ transient technology platform for triggering myocardial cell calcium release
Release time:
2025-07-02 16:11
Source:
Patch clamp induced Ca2+ transient technology platform
for triggering myocardial cell calcium release
1. Representative curve of calcium release:
Trigger calcium release by using patch clamp on the same myocardial cell.
They are the current induced by patch clamp (voltage clamp mode) and the triggered calcium release (Ca2+ transient).
2. Instruments:
Patch clamp and calcium release combination device.
3. Papers published on this platform:
Xie M, et al. Increased sarcoplasmic/endoplasmic reticulum calcium ATPase 2a activity underlies the mechanism of the positive inotropic effect of ivabradine. Exp Physiol. 2020; 105(3):477-488.
Link to paper:
https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/EP087964
4. Application fields:
This technology records the voltage or current of cells and observes their effect on calcium release, which is an important tool for studying excitation contraction coupling.
5. Technical support:
E-mail:longchen@njucm.edu.cn; Cellular phone: 13584058521
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Add: 8th Floor, Block D, No. 8 Taohongjing Road, Medical High-tech Zone, Taizhou City, Jiangsu
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