Rat heart pressure volume loop (P-V Loop) technology platform
Release time:
2025-07-02 16:10
Source:
Rat heart pressure volume loop (P-V Loop) technology platform
1. Indicators and representative curves of P-V Loop technology research:
Technical Indicators in Chinese and English
| HR | Heart rate | 心率 |
| SW | Stroke Work | 搏出功 |
| SV | Stroke Volume | 每搏输出功 |
| CO | Cardiac Output | 心输出量 |
| Pes | End-systolic Pressuret | 收缩末期心室压力 |
| Ped | End-diastolic Pressuret | 舒张末期心室压力 |
| Ves | End-systolic Volume | 收缩末期心室容积 |
| Ved | End-diastolic Volume | 舒张末期心室容积 |
| EF | Ejection Fraction | 射血分数 |
| RVU | Relative Volume Units | 容积相对平均值 |
| PV | Parallel volume | 平行容积 |
| +dP/dt max | Peak rate of rise of left ventricular pressure | 左心室压最大上升速率 |
| SBP | Systolic Blood Pressure | 动脉收缩压 |
| DBP | Diastolic Blood Pressure | 动脉舒张压 |
| LVDP | left ventricular developed pressure | 左心室发展压 |
| ATVC | Aortic valve closing time | 主动脉关闭时间 |
| E(t) | Time-varying driver function elastance | 时变弹性 |
| ESPVR | End-systolic Pressure-Volume relationship | 收缩末期压力-容积关系曲线 |
| EDPVR | End-diastolic Pressure-Volume relationship | 舒张末期的压力-容积关系曲线 |
| PVA | pressure volume area | 压力容积面积 |
| Ees | End-systolic elastance | 左心室收缩末期弹性 |
| Eed | End-diastolic stiffness, | 左心室舒张末期弹性 |
| Ea | Arterial Elasticity | 动脉阻抗 |
This figure illustrates the representative curves of Milrinone's effects on the P-V loop, left ventricular pressure, and peripheral arterial pressure in rat hearts.
2. Instruments:
PowerLab multi-channel physiological recorder (AD Instruments, Australia; Model: PowerLab 8/35); Millar amplifier (MILLAR Corporation, America；Model: 735-2083 Rev. F); Left ventricular pressure volume and aortic pressure catheter (MILLAR Corporation, America；Model: SPR-901).
3. Papers published on this platform:
(1) Wang YW, et al. Bay 60-7550, a PDE2 inhibitor, exerts positive inotropic effect of rat heart by increasing PKA-mediated phosphorylation of phospholamban. Eur J Pharmacol. 2021; 901:174077.
(2) Huang H, et al. Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a. Front. Pharmacol. 2019, 10:221.
(3) Xie M, et al. Increased sarcoplasmic/endoplasmic reticulum calcium ATPase 2a activity underlies the mechanism of the positive inotropic effect of ivabradine. Exp Physiol. 2020; 105(3):477-488.
Link to paper:
https://www.nstl.gov.cn/paper_detail.html?id=086facf46d8ce4c4e55ddc04e17bb65d
http://www.ncbi.nlm.nih.gov/pubmed/30967774
https://www.nstl.gov.cn/paper_detail.html?id=c8ef28fb7e637cedd88ea51f59f9d4bd
4. Application fields:
This technology involves the hemodynamics of the heart and peripheral blood vessels, and can analyze the mechanisms of action of all bioactive substances and drugs related to cardiovascular function; Perform protein translation functional analysis on mice with knocked out genes associated with cardiovascular function. Compared with traditional echocardiography techniques, this technique can simultaneously analyze the hemodynamics of peripheral blood vessels with higher accuracy.
5. Technical support:
E-mail:longchen@njucm.edu.cn; Cellular phone: 13584058521
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